Hematologic Malignancies

Hematological malignancies are forms of the cancer that begin in the cells of blood-forming tissue, such as the bone marrow, or in the cells of the immune system. Examples of hematologic cancer are acute and chronic leukemias, lymphomas, multiple myeloma and myelodysplastic syndromes. Genetic characterization is vital role in the clinical evaluation of nearly every form of hematologic malignancy. Here, we review how genetic analysis contributes to the diagnosis and/or management of acute leukemias, chronic myeloid neoplasms, B- and T-/natural killer (NK)-cell lymphomas, as well as multiple myeloma.